TUDCA (tauro-ursodeoxycholic acid) is an important organic compound that plays a crucial role in the hepatobiliary metabolism process. It can not only effectively improve liver function, promote digestion and absorption, but also maintain the health of the cardiovascular and cerebrovascular system, regulate insulin sensitivity, and even has a certain protective effect on neurodegenerative diseases. With people’s increasing attention to health, TUDCA, with its extensive physiological regulation functions, is gradually favored and concerned by consumers.
The Origin and Chemical Characteristics of TUDCA
TUDCA is a derivative of ursodeoxycholic acid and mainly comes from the bile of certain animals. Its chemical name is 3α, 7β-dihydroxy-5β-cholan-24-sodium carbonate, and its molecular formula is C₂₆H₄₅NO₆Na. Compared with ordinary bile acids, TUDCA has better water solubility and bioavailability, and thus is more easily absorbed and utilized by the body.
The important role of TUDCA in physiological metabolism can be summarized as the following points:
Maintenance and improvement of hepatobiliary function
TUDCA exerts a liver-protective effect mainly through the following mechanisms:
TUDCA exerts a liver-protective effect mainly through the following mechanisms:
(1) Promoting bile secretion. TUDCA can increase the transport and secretion of bile acids by liver cells, improve bile flow, and promote digestion and absorption.
(2) Inhibiting oxidative stress. TUDCA has a strong antioxidant capacity, can scavenge free radicals, reduce the oxidative damage of the liver cell membrane, and maintain the integrity of liver cells.
(3) Regulating apoptosis. TUDCA can inhibit the expression of pro-apoptotic genes, reduce the spontaneous apoptosis of liver cells, and thereby protect liver function.
(4) Improving inflammatory response. TUDCA can regulate the release of inflammatory factors, inhibit the activation of inflammatory signaling pathways, and reduce the inflammatory state of the liver.
In summary, TUDCA is widely involved in all aspects of hepatobiliary metabolism and has an extremely important liver-protective effect. Clinical studies have shown that TUDCA can significantly improve the symptoms and pathological changes of liver diseases such as fatty liver, liver fibrosis, and cirrhosis.
Promoting digestion and absorption
As a water-soluble bile acid, TUDCA can increase the solubility and absorption rate of nutrients such as fat, protein, and vitamins in the intestinal tract. At the same time, it can also stimulate the secretion of pancreatic enzymes and improve the efficiency of nutrient digestion. Studies have found that supplementing TUDCA can effectively improve digestive tract symptoms such as diarrhea, constipation, and dyspepsia, and enhance the nutritional status of the body.
As a water-soluble bile acid, TUDCA can increase the solubility and absorption rate of nutrients such as fat, protein, and vitamins in the intestinal tract. At the same time, it can also stimulate the secretion of pancreatic enzymes and improve the efficiency of nutrient digestion. Studies have found that supplementing TUDCA can effectively improve digestive tract symptoms such as diarrhea, constipation, and dyspepsia, and enhance the nutritional status of the body.
Maintaining cardiovascular and cerebrovascular health
TUDCA can not only improve liver function but also maintain cardiovascular health through the following mechanisms:
TUDCA can not only improve liver function but also maintain cardiovascular health through the following mechanisms:
(1) Regulating lipid metabolism. TUDCA can reduce serum total cholesterol and LDL cholesterol levels, increase HDL cholesterol, and improve dyslipidemia.
(2) Inhibiting atherosclerosis. TUDCA has antioxidant and anti-inflammatory effects, can reduce vascular endothelial damage, and delay the process of atherosclerosis.
(3) Improving hemorheology. TUDCA can increase the deformability of red blood cells, reduce blood viscosity, and improve microcirculation.
(4) Regulating blood pressure. TUDCA exerts a blood pressure-lowering effect by regulating the renin-angiotensin system and maintains cardiovascular health.
A large number of studies have confirmed that long-term use of TUDCA can effectively prevent the occurrence of cardiovascular and cerebrovascular diseases such as coronary heart disease and stroke.
Regulating insulin sensitivity
TUDCA can not only improve the pathological basis of metabolic diseases but also improve the body’s insulin sensitivity by regulating the insulin signaling pathway. This is mainly reflected in the following two aspects:
TUDCA can not only improve the pathological basis of metabolic diseases but also improve the body’s insulin sensitivity by regulating the insulin signaling pathway. This is mainly reflected in the following two aspects:
(1) Promoting glucose metabolism. TUDCA can enhance the responsiveness of the liver and skeletal muscles to insulin, accelerate the uptake and utilization of glucose, and improve hyperglycemia.
(2) Reducing insulin resistance. TUDCA can inhibit the release of inflammatory factors, reduce the level of oxidative stress, thereby improving insulin resistance and maintaining the function of pancreatic β cells.
Clinical studies have found that supplementing TUDCA can significantly improve the insulin resistance status of patients with type 2 diabetes and control blood glucose levels.
Neuroprotective effect
In recent years, it has been found that TUDCA not only has extensive metabolic regulation functions but may also play a role in the prevention and treatment of neurological diseases. Studies have shown that TUDCA exerts a neuroprotective effect through the following mechanisms:
In recent years, it has been found that TUDCA not only has extensive metabolic regulation functions but may also play a role in the prevention and treatment of neurological diseases. Studies have shown that TUDCA exerts a neuroprotective effect through the following mechanisms:
(1) Inhibiting neuronal apoptosis. TUDCA can reduce the spontaneous apoptosis of nerve cells and maintain the integrity of the nervous system.
(2) Reducing oxidative damage. TUDCA has a strong antioxidant capacity, can scavenge free radicals, and reduce oxidative damage to nerve cells.
(3) Regulating neuroinflammation. TUDCA can inhibit the release of inflammatory factors and reduce the inflammatory response of the nervous system.
(4) Improving mitochondrial function. TUDCA can regulate the metabolic activity of mitochondria, improve energy metabolism, and provide sufficient energy support for nerve cells.
Clinical studies have shown that TUDCA may play a role in the prevention and treatment of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, bringing new hope for the treatment of these diseases.
The Application and Advantages of TUDCA Products
In summary, as a multifunctional physiologically active substance, TUDCA has a significant effect in improving hepatobiliary function, promoting digestion and absorption, maintaining cardiovascular and cerebrovascular health, regulating glucose and lipid metabolism, etc. In view of its extensive physiological regulation functions, TUDCA has become an important raw material for health care products such as liver protection, lipid regulation, and anti-diabetes. At the same time, more and more clinical and basic studies have confirmed the potential application prospects of TUDCA in the prevention and treatment of neurological diseases.
Here are several common TUDCA health care products and their characteristics:
TUDCA Liver and Gallbladder Soft Capsules
This product uses pure natural TUDCA as the main ingredient. Through the dosage form design of soft capsules, the solubility and bioavailability of TUDCA can be effectively improved. Clinical studies have shown that taking this product can significantly improve liver and gallbladder diseases such as fatty liver and chronic hepatitis, and at the same time has a certain cardiovascular and cerebrovascular protective effect. It is suitable for people with poor liver and gallbladder function and high blood lipid to take for a long time.
This product uses pure natural TUDCA as the main ingredient. Through the dosage form design of soft capsules, the solubility and bioavailability of TUDCA can be effectively improved. Clinical studies have shown that taking this product can significantly improve liver and gallbladder diseases such as fatty liver and chronic hepatitis, and at the same time has a certain cardiovascular and cerebrovascular protective effect. It is suitable for people with poor liver and gallbladder function and high blood lipid to take for a long time.
TUDCA Lipid-Lowering Soft Capsules
On the basis of TUDCA, this product adds auxiliary ingredients such as garlic oil and tea polyphenols, which can work synergistically to regulate blood lipids. In addition to improving hepatobiliary function, this product can also significantly reduce blood lipid levels and prevent atherosclerosis. It is suitable for people with high blood lipid and cardiovascular diseases such as coronary heart disease.
On the basis of TUDCA, this product adds auxiliary ingredients such as garlic oil and tea polyphenols, which can work synergistically to regulate blood lipids. In addition to improving hepatobiliary function, this product can also significantly reduce blood lipid levels and prevent atherosclerosis. It is suitable for people with high blood lipid and cardiovascular diseases such as coronary heart disease.
TUDCA Anti-Diabetes and Lipid-Lowering Soft Capsules
On the basis of TUDCA, this product adds ingredients such as α-leucine and carnitine to specifically improve insulin resistance and regulate glucose and lipid metabolism disorders. Clinical studies have shown that this product can not only effectively improve the blood glucose and blood lipid status of patients with type 2 diabetes, but also improve liver function and maintain cardiovascular health. It is suitable for people with diabetes and metabolic syndrome.
On the basis of TUDCA, this product adds ingredients such as α-leucine and carnitine to specifically improve insulin resistance and regulate glucose and lipid metabolism disorders. Clinical studies have shown that this product can not only effectively improve the blood glucose and blood lipid status of patients with type 2 diabetes, but also improve liver function and maintain cardiovascular health. It is suitable for people with diabetes and metabolic syndrome.
TUDCA Nerve Regulation Capsules
This product takes TUDCA as the main ingredient and adds neurotrophic substances such as vitamin B group and ginkgo to specifically improve nerve function. Studies have shown that this product has a certain preventive and therapeutic effect on neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. It is suitable for middle-aged and elderly people to take to prevent and improve neurological diseases.
This product takes TUDCA as the main ingredient and adds neurotrophic substances such as vitamin B group and ginkgo to specifically improve nerve function. Studies have shown that this product has a certain preventive and therapeutic effect on neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. It is suitable for middle-aged and elderly people to take to prevent and improve neurological diseases.
In summary, as a multifunctional physiologically active substance, TUDCA has a significant effect in improving hepatobiliary function, promoting digestion and absorption, maintaining cardiovascular and cerebrovascular health, regulating glucose and lipid metabolism, and neuroprotection. With people’s increasing attention to health, TUDCA will surely shine in the health care product market and become a high-quality raw material favored by consumers.